HARRISON’S Manual of Medicine

CONTENTS

Contributors xiii
Preface xv
SECTION 1
CARE OF THE HOSPITALIZED PATIENT
1 Initial Evaluation and
Admission Orders for the
General Medicine Patient 1
2 Assessment of Nutritional
Status 2
3 Electrolytes/Acid-Base
Balance 5
4 Enteral and Parenteral
Nutrition 14
5 Transfusion and Pheresis
Therapy 17
6 Principles of Critical Care
Medicine 19
7 Respiratory Failure 22
8 Pain and Its Management 23
9 Procedures Commonly
Performed by Internists 28
10 Diagnostic Imaging in
Internal Medicine 32
11 Gastrointestinal Diseases 34
SECTION 2
MEDICAL EMERGENCIES
12 Acute Respiratory Distress
Syndrome (ARDS) 39
13 Cardiovascular Collapse
and Sudden Death 41
14 Shock 44
15 Sepsis and Septic Shock 49
16 Acute Pulmonary Edema 53
17 Confusion, Stupor,
and Coma 54
18 Stroke 58
19 Subarachnoid Hemorrhage 66
20 Increased Intracranial
Pressure and Head Trauma 67
21 Hypoxic-Ischemic
Encephalopathy 69
22 Status Epilepticus 72
23 Poisoning and Drug
Overdose 74
24 Diabetic Ketoacidosis and
Hyperosmolar Coma 89
25 Hypoglycemia 91
26 Infectious Disease
Emergencies 94
27 Oncologic Emergencies 101
28 Anaphylaxis 105
29 Bites, Venoms, Stings, and
Marine Poisonings 106
30 Hypothermia and Frostbite 115
31 Bioterrorism 118
SECTION 3
COMMON PATIENT PRESENTATIONS
32 Chest Pain 133
33 Abdominal Pain 136
34 Headache 139
35 Back and Neck Pain 147
36 Fever, Hyperthermia,
Chills, and Rash 156
37 Pain or Swelling of Joints 161
38 Syncope and Faintness 164
39 Dizziness and Vertigo 168
40 Acute Visual Loss and
Double Vision 171
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41 Paralysis and Movement
Disorders 175
42 Aphasias and Related
Disorders 179
43 SleepDisorders 181
44 Dyspnea 185
45 Cough and Hemoptysis 187
46 Cyanosis 192
47 Edema 194
48 Nausea, Vomiting, and
Indigestion 197
49 Weight Loss 201
50 Dysphagia 203
51 Acute Abdomen 206
52 Diarrhea, Constipation, and
Malabsorption 208
53 Gastrointestinal Bleeding 214
54 Jaundice and Evaluation of
Liver Function 218
55 Ascites 224
56 Azotemia and Urinary
Abnormalities 227
57 Anemia and Polycythemia 232
58 Lymphadenopathy and
Splenomegaly 235
SECTION 4
DISORDERS OF THE EYE, EAR, NOSE, AND THROAT
59 Common Disorders of
Vision and Hearing 241
60 Infections of the Upper
Respiratory Tract 248
SECTION 5
DERMATOLOGY
61 General Examination of
the Skin 255
62 Common Skin Conditions 259
SECTION 6
HEMATOLOGY AND ONCOLOGY
63 Examination of Blood
Smears and Bone Marrow 265
64 Red Blood Cell Disorders 267
65 Leukocytosis and
Leukopenia 272
66 Bleeding and Thrombotic
Disorders 275
67 Prevention and Early
Detection of Cancer 280
68 Cancer Chemotherapy 284
69 Myeloid Leukemias,
Myelodysplasia, and
Myeloproliferative
Syndrome 290
70 Lymphoid Malignancies 296
71 Skin Cancer 307
72 Head and Neck Cancer 309
73 Lung Cancer 310
74 Breast Cancer 316
75 Tumors of the
Gastrointestinal Tract 320
76 Genitourinary Tract Cancer 331
77 Gynecologic Cancer 334
78 Prostate Hyperplasia and
Carcinoma 338
79 Cancer of Unknown
Primary Site 341
80 Paraneoplastic Endocrine
Syndromes 344
81 Neurologic Paraneoplastic
Syndromes 346
vi CONTENTS
SECTION 7
INFECTIOUS DISEASES
82 Diagnosis of Infectious
Diseases 351
83 Antibacterial Therapy 360
84 Immunization andAd vice
to Travelers 365
85 Infective Endocarditis 372
86 Intraabdominal Infections 380
87 Infectious Diarrheas 383
88 Sexually Transmitted
Diseases andReprod uctive
Tract Infections 393
89 Infections of the Skin, Soft
Tissues, Joints, andBones 408
90 Infections in the
ImmunocompromisedHost 417
91 HIV Infection andAIDS 424
92 Hospital-AcquiredInfections 442
93 Pneumococcal Infections 445
94 Staphylococcal Infections 448
95 Streptococcal/Enterococcal
Infections, Diphtheria, and
Other Corynebacterial
Infections 455
96 Meningococcal andListerial
Infections 462
97 Infections Causedby
Haemophilus, Bordetella,
Moraxella, andHACEK
Group Organisms 466
98 Diseases Causedby Gram-
Negative Enteric Bacteria,
Pseudomonas, and
Legionella 471
99 Infections Causedby Other
Gram-Negative Bacilli 479
100 Anaerobic Infections 485
101 Nocardiosis and
Actinomycosis 492
102 Tuberculosis andOther
Mycobacterial Infections 495
103 Lyme Disease andOther
Nonsyphilitic Spirochetal
Infections 506
104 Rickettsial Diseases 510
105 Mycoplasma Infections 516
106 Chlamydial Infections 517
107 Herpesvirus Infections 520
108 Cytomegalovirus and
Epstein-Barr Virus
Infections 529
109 Influenza andOther Viral
Respiratory Diseases 533
110 Rubeola, Rubella, Mumps,
andParvovirus Infections 539
111 Enteroviral Infections 544
112 Insect- andAnimal-Borne
Viral Infections 547
113 Fungal Infections 555
114 Pneumocystis Infection 565
115 Protozoal Infections 569
116 Helminthic Infections 580
SECTION 8
CARDIOVASCULAR DISEASES
117 Physical Examination of the
Heart 593
118 Electrocardiography and
Echocardiography 596
119 Valvular Heart Disease 603
120 Cardiomyopathies and
Myocarditis 609
121 Pericardial Disease 612
122 Hypertension 616
123 ST-Segment Elevation
Myocardial Infarction
(STEMI) 621
124 Chronic Stable Angina,
Unstable Angina, andNon-
ST-Elevation Myocardial
Infarction 631
CONTENTS vii
125 Arrhythmias 638
126 Congestive Heart Failure
and Cor Pulmonale 648
127 Diseases of the Aorta 653
128 Peripheral Vascular Disease 655
129 Pulmonary Hypertension 658
SECTION 9
RESPIRATORY DISEASES
130 Respiratory Function and
Pulmonary Diagnostic
Procedures 663
131 Asthma and Hypersensitivity
Pneumonitis 668
132 Environmental Lung
Diseases 673
133 Chronic Bronchitis,
Emphysema, and Acute
or Chronic Respiratory
Failure 675
134 Pneumonia and Lung
Abscess 679
135 Pulmonary
Thromboembolism 685
136 Interstitial Lung Disease
(ILD) 687
137 Diseases of the Pleura,
Mediastinum, and
Diaphragm 691
138 Disorders of Ventilation,
Including SleepAp nea 695
SECTION 10
RENAL DISEASES
139 Approach to the Patient with
Renal Disease 699
140 Acute Renal Failure 702
141 Chronic Kidney Disease
(CKD) and Uremia 707
142 Dialysis 709
143 Renal Transplantation 711
144 Glomerular Diseases 713
145 Renal Tubular Disease 720
146 Urinary Tract Infections 724
147 Renovascular Disease 728
148 Nephrolithiasis 731
149 Urinary Tract Obstruction 734
SECTION 11
GASTROINTESTINAL DISEASES
150 Peptic Ulcer and Related
Disorders 737
151 Inflammatory Bowel
Diseases 742
152 Colonic and Anorectal
Diseases 746
153 Cholelithiasis, Cholecystitis,
and Cholangitis 749
154 Pancreatitis 753
155 Acute Hepatitis 757
156 Chronic Hepatitis 762
157 Cirrhosis and Alcoholic
Liver Disease 766
158 Portal Hypertension 769
viii CONTENTS
SECTION 12
ALLERGY, CLINICAL IMMUNOLOGY, AND RHEUMATOLOGY
159 Diseases of Immediate
Type Hypersensitivity 773
160 Primary Immunodeficiency
Diseases 776
161 SLE, RA, and Other
Connective Tissue
Diseases 779
162 Vasculitis 785
163 Ankylosing Spondylitis 788
164 Psoriatic Arthritis 791
165 Reactive Arthritis and
Reiter’s Syndrome 792
166 Osteoarthritis 794
167 Gout, Pseudogout, and
Related Diseases 796
168 Other Arthritides 799
169 Sarcoidosis 802
170 Amyloidosis 804
SECTION 13
ENDOCRINOLOGY AND METABOLISM
171 Disorders of the Anterior
Pituitary and Hypothalamus 807
172 Disorders of the Posterior
Pituitary 813
173 Disorders of the Thyroid 815
174 Disorders of the Adrenal
Gland 823
175 Obesity 828
176 Diabetes Mellitus 830
177 Disorders of the Male
Reproductive System 835
178 Disorders of the Female
Reproductive System 839
179 Hypercalcemic and
Hypocalcemic Disorders 847
180 Osteoporosis and
Osteomalacia 852
181 Disorders of Lipid
Metabolism 855
182 Hemochromatosis,
Porphyrias, and Wilson’s
Disease 861
SECTION 14
NEUROLOGY
183 The Neurologic
Examination 867
184 Neuroimaging 873
185 Seizures and Epilepsy 875
186 Tumors of the Nervous
System 883
187 Acute Meningitis and
Encephalitis 886
188 Chronic Meningitis 896
189 Multiple Sclerosis (MS) 899
190 Alzheimer’s Disease and
Other Dementias 904
191 Parkinson’s Disease 910
192 Ataxic Disorders 914
193 ALS and Other Motor
Neuron Diseases 917
194 Trigeminal Neuralgia,
Bell’s Palsy, and Other
Cranial Nerve Disorders 920
195 Autonomic Nervous
System Disorders 925
196 Spinal Cord Diseases 932
197 Peripheral Neuropathies,
Including Guillain-Barre´
Syndrome 936
198 Myasthenia Gravis (MG) 942
199 Muscle Diseases 944
200 Chronic Fatigue Syndrome 952
CONTENTS ix
SECTION 15
PSYCHIATRIC DISORDERS AND PSYCHOACTIVE SUBSTANCE USE
201 Psychiatric Disorders 955
202 Psychiatric Medications 962
203 Eating Disorders 969
204 Alcoholism 972
205 Narcotic Abuse 975
SECTION 16
ADVERSE DRUG REACTIONS
206 Adverse Drug Reactions 979
SECTION 17
WOMEN’S HEALTH
207 Women’s Health 989
SECTION 18
SCREENING AND DISEASE PREVENTION
208 Health Maintenance and
Disease Prevention 991
SECTION 19
LABORATORY VALUES
209 Appendix: Laboratory
Values of Clinical
Importance 995
Index 1011

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